Table 1.
Clinical and Neuropathological Case Characteristics
| NCI (N=11) | MCI (N=11) | AD (N=9) | Overall p-value | Pair-wise comparisons | ||
|---|---|---|---|---|---|---|
| Age (years) at death | Mean ± SD | 86.17 ± 4.95 | 87.36 ± 4.58 | 88.48 ± 5.36 | 0.59 | ----- |
| Number of males (%) | 3 (27) | 18 (33) | 3 (33) | 0.74 | ----- | |
| Years of education | Mean ± SD | 16.91 ± 3.65 | 18.36 ± 2.80 | 18.22 ± 4.02 | 0.57 | ----- |
| Number with ApoE ε4 allele (%) | 0 (0) | 5 (45) | 2 (22) | 0.04 | ----- | |
| MMSE | Mean ± SD | 28.00 ± 1.55 | 26.91 ± 2.91 | 20.33 ± 2.43 | <0.001 | NCI, MCI > AD |
| GCS | Mean ± SD | −0.16 ± 0.25 | −0.41 ± 0.44 | −1.27 ± 0.68 | <0.001 | NCI, MCI > AD |
| Episodic memory z-score | Mean ± SD | 0.23 ± 0.45 | −0.33 ± 0.65 | −1.68 ± 1.15 | <0.001 | NCI, MCI > AD |
| Semantic memory z-score | Mean ± SD | −0.42 ± 0.65 | −0.37 ± 0.71 | −0.74 ± 0.77 | 0.46 | ----- |
| Working memory z-score | Mean ± SD | −0.18 ± 0.49 | −0.19 ± 0.69 | −0.58 ± 0.59 | 0.25 | ----- |
| Perceptual speed z-score | Mean ± SD | −0.71 ± 0.66 | −0.84 ± 0.59 | −2.40 ± 0.72 | <0.001 | NCI, MCI > AD |
| Visuospatial z-score | Mean ± SD | −0.41 ± 0.53 | −0.80 ± 0.63 | −1.12 ± 0.89 | 0.08 | ---- |
| Post-mortem interval (hours) | Mean ± SD | 5.38 ± 2.11 | 5.44 ± 2.18 | 4.14 ± 1.43 | 0.27 | ----- |
| Brain weight (g) | Mean ± SD | 1166.91 ± 86.22 | 1154.27 ± 141.18 | 1150.56 ± 88.26 | 0.83 | ----- |
| Distribution of Braak scores | 0 | 0 | 0 | 0 | 0.76 | ----- |
| I/II | 2 | 2 | 1 | |||
| III/IV | 8 | 5 | 6 | |||
| V/VI | 1 | 4 | 2 | |||
| NIA Reagan (likelihood of AD) | No AD | 0 | 0 | 0 | 0.17 | ----- |
| Low | 6 | 3 | 1 | |||
| Intermediate | 5 | 5 | 6 | |||
| High | 0 | 3 | 2 | |||
| CERAD | No AD | 2 | 2 | 0 | 0.10 | ----- |
| Possible | 6 | 6 | 6 | |||
| Probable | 3 | 0 | 0 | |||
| Definite | 0 | 3 | 3 | |||