Table 3.
Differentially expressed transcripts in PreC CatD-positive layer III neurons in MCI compared to NCI
| Gene | Gene Ontology Category Group | Gene Full Name | p | FDR | MCI |
|---|---|---|---|---|---|
| MAPT2N6D | AD | truncated tau 6D isoform with E2 and E3 | 0.003 | 0.305 | ↑ |
| IAPP | AD | islet amyloid polypeptide alias amylin | 0.005 | 0.305 | ↓ |
| MAPT1N6P | AD | truncated tau 6P isoform with only E2 | 0.01 | 0.452 | ↑ |
| BCL2 | CD | B-cell CLL/lymphoma 2 | 0.01 | 0.452 | ↑ |
| NES | CYT | nestin | 0.005 | 0.305 | ↓ |
| NEFH | CYT | neurofilament, heavy polypeptide | 0.008 | 0.452 | ↓ |
| DNCLC1 | CYT | dynein light chain LC8-type 1 | 0.01 | 0.452 | ↑ |
| RAB4A | EALS | RAB4A, member RAS oncogene family | 0.003 | 0.305 | ↑ |
| BECN1 | EALS | beclin 1, autophagy related | 0.03t | 0.468 | ↑ |
| EPHA2 | PP/K | EPH receptor A2; epithelial cell protein tyrosine kinase | 0.04t | 0.594 | ↓ |
| GR1K5 | GLUR | glutamate receptor ionotropic kainate 5 | 0.03t | 0.468 | ↓ |
| GR1N2C | GLUR | glutamate receptor, ionotropic NMDA 2C | 0.003 | 0.305 | ↑ |
| CART | MONO | cocaine- and amphetamine-regulated transcript | 0.04t | 0.594 | ↓ |
| GABRA1 | GABA | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 0.01 | 0.452 | ↓ |
| CACNA1B | CH | calcium channel, voltage-dependent, N type, alpha 1B subunit | 0.01 | 0.452 | ↓ |
| DPP6 | CH | dipeptidyl-peptidase 6 | 0.02t | 0.468 | ↑ |
| DPP10 | CH | dipeptidyl-peptidase 10 | 0.004 | 0.305 | ↑ |
| MSR1 | GLIA | macrophage scavenger receptor 1 | 0.04t | 0.594 | ↓ |
| PSA | PEP | aminopeptidase puromycin sensitive | 0.008 | 0.452 | ↑ |
: trend level change.