Table 4.
Differentially expressed transcripts in PreC CatD-positive layer III neurons in AD compared to NCI
| Gene | Gene Oncology Category Group | Gene Full name | p | FDR | AD |
|---|---|---|---|---|---|
| SAA4 | AD | serum amyloid A4 | 0.01 | 0.211 | ↑ |
| NCSTN | AD | nicastrin | 0.01 | 0.211 | ↑ |
| HDLBP | AD | high density lipoprotein binding protein | 0.02t | 0.351 | ↑ |
| APCS | AD | amyloid P component, serum | 0.03t | 0.351 | ↑ |
| BCL2 | CD | B-cell CLL/lymphoma 2 | 0.01 | 0.211 | ↑ |
| NEFL | CYT | neurofilament, light polypeptide | 0.0002 | 0.035 | ↑ |
| NEFM | CYT | neurofilament, medium polypeptide | 0.002 | 0.073 | ↑ |
| ACTB | CYT | β-actin | 0.002 | 0.073 | ↑ |
| DNCLC1 | CYT | dynein light chain LC8-type 1 | 0.002 | 0.096 | ↑ |
| MAP2 | CYT | microtubule-associated protein 2 | 0.008 | 0.211 | ↑ |
| CLTC | CYT | clathrin, heavy polypeptide (He) | 0.04t | 0.357 | ↑ |
| RAB11A | EALS | RAB11 A, member RAS oncogene family | 0.009 | 0.211 | ↑ |
| LAMP1 | EALS | lysosomal-associated membrane protein 1 | 0.008 | 0.211 | ↓ |
| ATG10 | EALS | autophagy related 10 | 0.002 | 0.073 | ↓ |
| CTSC | EALS | cathepsin C | 0.046t | 0.357 | ↑ |
| RAB5A | EALS | RAB5A, member RAS oncogene family | 0.01 | 0.211 | ↑ |
| PPT1 | EALS | palmitoyl-protein thioesterase 1 | 0.02t | 0.351 | ↓ |
| GNG2 | GP | guanine nucleotide binding protein (G protein), gamma 2 | 0.0008 | 0.073 | ↓ |
| RGS9 | GP | regulator of G-protein signaling 9 | 0.04t | 0.357 | ↑ |
| RGS13 | GP | regulator of G-protein signaling 13 | 0.04t | 0.357 | ↑ |
| PPP3CC | PP/K | protein phosphatase 3, catalytic subunit, gamma isoform | 0.0003 | 0.052 | ↑ |
| RPS6KB1 | PP/K | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.01 | 0.211 | ↓ |
| PRKCE | PP/K | protein kinase C, epsilon | 0.02t | 0.211 | ↑ |
| TIMP1 | PROT | tissue inhibitor of metalloproteinase 1 | 0.009 | 0.211 | ↑ |
| GLRX | PROT | glutaredoxin (thioltransferase) | 0.04t | 0.351 | ↑ |
| CAST | PROT | calpastatin | 0.04t | 0.357 | ↑ |
| HSD17B1 | ST | hydroxysteroid (17-beta) dehydrogenase 1 | 0.0004 | 0.073 | ↑ |
| NR5A1/SF1 | ST | nuclear receptor subfamily 5, group A, member 1 | 0.002 | 0.073 | ↑ |
| NCOR2 | ST | nuclear receptor corepressor 2 | 0.01 | 0.211 | ↓ |
| NR4A2 | ST | nuclear receptor subfamily 4, group A, member 2 alias NURR1 | 0.04t | 0.357 | ↑ |
| NR3C1 | ST | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.046t | 0.357 | ↓ |
| GRIK3 | GLUR | glutamate receptor ionotropic kainate 3 | 0.003 | 0.096 | ↑ |
| GRM1 | GLUR | glutamate receptor, metabotropic 1 | 0.004 | 0.211 | ↑ |
| GRM2 | GLUR | glutamate receptor, metabotropic 2 | 0.02t | 0.211 | ↑ |
| GRM5 | GLUR | glutamate receptor, metabotropic 5 | 0.009 | 0.211 | ↑ |
| GRIN2B | GLUR | glutamate receptor, ionotropic NMDA 2B | 0.03t | 0.351 | ↑ |
| GRIA1 | GLUR | glutamate receptor ionotropic AMPA 1 | 0.045t | 0.357 | ↓ |
| SLC2A4 | GLUC | solute carrier family 2 (glucose transporter), member 4 | 0.02t | 0.211 | ↑ |
| SLC2A5 | GLUC | solute carrier family 2 (glucose transporter), member 5 | 0.002 | 0.073 | ↓ |
| SLC2A3 | GLUC | solute carrier family 2 (glucose transporter), member 3 | 0.001 | 0.073 | ↑ |
| SLC6A4/SERT | MONO | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, | 0.003 | 0.211 | ↑ |
| SLC6A2/NET | MONO | solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 | 0.01 | 0.211 | ↑ |
| CHRNB4 | MONO | cholinergic receptor, nicotinic, beta 4 | 0.03t | 0.351 | ↓ |
| DRD3 | MONO | dopamine receptor D3 | 0.03t | 0.351 | ↓ |
| CART | MONO | cocaine- and amphetamine-regulated transcript | 0.03t | 0.351 | ↓ |
| DRD4 | MONO | dopamine receptor D4 | 0.04t | 0.351 | ↑ |
| ADRA2A | MONO | adrenergic receptor, alpha 2a | 0.04t | 0.351 | ↓ |
| CHAT | MONO | choline acetyltransferase | 0.04t | 0.351 | ↑ |
| CHRNA2 | MONO | cholinergic receptor, nicotinic, alpha2 | 0.03t | 0.351 | ↑ |
| BCHE | MONO | butyrylcholinesterase | 0.02t | 0.211 | ↑ |
| CHRNA5 | MONO | cholinergic receptor, nicotinic, alpha5 | 0.02t | 0.211 | ↑ |
| DRD2 | MONO | dopamine receptor D2 | 0.02t | 0.211 | ↑ |
| CHRNA4 | MONO | cholinergic receptor, nicotinic, alpha4 | 0.02t | 0.211 | ↑ |
| GABRA1 | GABA | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 0.02t | 0.211 | ↓ |
| GABRG3 | GABA | gamma-aminobutyric acid (GABA) A receptor, gamma 3 | 0.03t | 0.351 | ↑ |
| GABRA4 | GABA | gamma-aminobutyric acid (GABA) A receptor, alpha 4 | 0.006 | 0.211 | ↑ |
| GABBR1 | GABA | gamma-aminobutyric acid (GABA) B receptor, 1 | 0.02t | 0.211 | ↑ |
| KCNIP1 | CH | Kv channel interacting protein 1 | 0.03t | 0.351 | ↓ |
| KCNA2 | CH | potassium voltage-gated channel, shaker-related subfamily, member 2 | 0.02t | 0.211 | ↓ |
| CACNA1B | CH | calcium channel, voltage-dependent, N type, alpha 1B subunit | 0.005 | 0.211 | ↓ |
| MSR1 | GLIA | macrophage scavenger receptor 1 | 3.40E-06 | 0.035 | ↓ |
| CSF1 | GLIA | colony stimulating factor 1 (macrophage) | 0.02t | 0.351 | ↑ |
| HOMER1 | SYN | homer homolog 1 | 0.03t | 0.351 | ↑ |
| SNCB | SYN | synuclein, beta | 0.049t | 0.357 | ↑ |
| ERCC1 | TF | excision repair cross-complementing rodent repair deficiency, complementation group 1 | 0.0002 | 0.035 | ↑ |
| DAB1 | DV | disabled 1 | 0.04t | 0.351 | ↑ |
| IGF2R | NT | insulin-like growth factor 2 receptor | 0.04t | 0.357 | ↑ |
t
: trend level change