Table 5.
Differentially expressed transcripts in PreC CatD-positive layer III neurons in AD compared to MCI
| Gene | Gene Oncology Category Group | Gene Full name | p | FDR | AD |
|---|---|---|---|---|---|
| HDLBP | AD | high density lipoprotein binding protein | 0.0008 | 0.122 | ↑ |
| APP | AD | amyloid beta (A4) precursor protein | 0.003 | 0.137 | ↑ |
| SAA4 | AD | serum amyloid A4 | 0.004 | 0.137 | ↑ |
| B2M | AD | beta-2-microglobulin | 0.01 | 0.181 | ↑ |
| LRP1 | AD | low density lipoprotein receptor-related protein 1 alias A2MR | 0.02t | 0.230 | ↑ |
| NCSTN | AD | nicastrin | 0.03t | 0.233 | ↑ |
| EPYC/ | AD | epiphycan | 0.04t | 0.233 | ↑ |
| NEFL | CYT | neurofilament, light polypeptide | 0.0008 | 0.069 | ↑ |
| ACTB | CYT | β-actin | 0.04t | 0.233 | ↑ |
| NEFM | CYT | neurofilament, medium polypeptide | 0.01 | 0.181 | ↑ |
| TUBA1 | CYT | tubulin, alpha 1 | 0.0499t | 0.283 | ↑ |
| MAP2 | CYT | microtubule-associated protein 2 | 0.04t | 0.233 | ↑ |
| MYO5B | EALS | myosin VB | 0.006 | 0.137 | ↑ |
| RAB11A | EALS | RAB11 A, member RAS oncogene family | 0.04t | 0.233 | ↑ |
| BECN1 | EALS | beclin 1, autophagy related | 0.002 | 0.122 | ↓ |
| LAMP1 | EALS | lysosomal-associated membrane protein 1 | 0.005 | 0.137 | ↓ |
| RGS9 | GP | regulator of G-protein signaling 9 | 0.03t | 0.233 | ↑ |
| GNG2 | GP | guanine nucleotide binding protein (G protein), gamma 2 | 0.01 | 0.181 | ↓ |
| PPP3CC | PP/K | protein phosphatase 3, catalytic subunit, gamma isoform | 0.009 | 0.181 | ↑ |
| RPS6KB1 | PP/K | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.01 | 0.181 | ↓ |
| PPP2CA | PP/K | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 0.02t | 0.230 | ↓ |
| SOD1 | PROT | superoxide dismutase 1 | 0.02t | 0.181 | ↑ |
| SOD2 | PROT | superoxide dismutase 2 | 0.02t | 0.181 | ↑ |
| TIMP1 | PROT | tissue inhibitor of metalloproteinase 1 | 0.04t | 0.233 | ↑ |
| HSD17B1 | ST | hydroxysteroid (17-beta) dehydrogenase 1 | 0.002 | 0.122 | ↑ |
| NR5A1/SF1 | ST | nuclear receptor subfamily 5, group A, member 1 | 0.006 | 0.137 | ↑ |
| NR3C1 | ST | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.02t | 0.181 | ↓ |
| NCOR2 | ST | nuclear receptor corepressor 2 | 0.02t | 0.230 | ↓ |
| GRM1 | GLUR | glutamate receptor, metabotropic 1 | 0.003 | 0.122 | ↑ |
| GRM2 | GLUR | glutamate receptor, metabotropic 2 | 0.007 | 0.149 | ↑ |
| GRM5 | GLUR | glutamate receptor, metabotropic 5 | 0.01 | 0.181 | ↑ |
| GRM7 | GLUR | glutamate receptor, metabotropic 7 | 0.03t | 0.233 | ↑ |
| GRM8 | GLUR | glutamate receptor, metabotropic 8 | 0.02t | 0.181 | ↑ |
| GRIK2 | GLUR | glutamate receptor ionotropic kainate 2 | 0.006 | 0.137 | ↑ |
| GRIN2D | GLUR | glutamate receptor, ionotropic NMDA 2D | 0.003 | 0.122 | ↑ |
| SLC1A3/EAAT1 | GLUR | solute carrier family 1 (glial high-affinity glutamate transporter), member 3 | 0.03t | 0.233 | ↑ |
| SLC2A5 | GLUC | solute carrier family 2 (facilitated glucose transporter), member 5 | 0.004 | 0.137 | ↓ |
| BCHE | MONO | butyrylcholinesterase | 0.02t | 0.230 | ↑ |
| CHAT | MONO | choline acetyltransferase | 0.005 | 0.137 | ↑ |
| SLC6A4/SERT | MONO | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, | 0.0005 | 0.069 | ↑ |
| CHRM1 | MONO | cholinergic receptor, muscarinic 1 | 0.03t | 0.233 | ↑ |
| CHRM3 | MONO | cholinergic receptor, muscarinic 3 | 0.01 | 0.181 | ↑ |
| CHRNA1 | MONO | cholinergic receptor, nicotinic, alphal | 0.046t | 0.283 | ↑ |
| CHRNA2 | MONO | cholinergic receptor, nicotinic, alpha2 | 0.02t | 0.181 | ↑ |
| CHRNA4 | MONO | cholinergic receptor, nicotinic, alpha4 | 0.003 | 0.137 | ↑ |
| DRD2 | MONO | dopamine receptor D2 | 0.002 | 0.1221 | ↑ |
| DRD4 | MONO | dopamine receptor D4 | 0.02t | 0.181 | ↑ |
| HTR3A | MONO | 5-hydroxytryptamine (serotonin) receptor 3A | 0.03t | 0.233 | ↑ |
| SLC6A11/GAT4 | GABA | solute carrier family 6 (neurotransmitter transporter, GABA), member 11 | 0.03t | 0.233 | ↑ |
| SLC6A13/GAT3 | GABA | solute carrier family 6 (neurotransmitter transporter, GABA), member 13 | 0.04t | 0.283 | ↑ |
| KCNA2 | CH | potassium voltage-gated channel, shaker-related subfamily, member 2 | 0.049t | 0.283 | ↓ |
| KCNA6 | CH | potassium voltage-gated channel, shaker-related subfamily, member 6 | 0.04t | 0.233 | ↓ |
| DPP6 | CH | dipeptidyl-peptidase 6 | 0.03t | 0.233 | ↓ |
| DPP10 | CH | dipeptidyl-peptidase 10 | 0.02t | 0.181 | ↓ |
| HSP90AA1 | GLIA | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.02t | 0.181 | ↑ |
| DNAJA1 | GLIA | DnaJ (Hsp40) homolog, subfamily A, member 1 alias HDJ2 | 0.03t | 0.233 | ↑ |
| MSR1 | GLIA | macrophage scavenger receptor 1 | 0.0001 | 0.052 | ↓ |
| ERBB2IP | SYN | erbb2 interacting protein densin-180 | 0.006 | 0.137 | ↑ |
| DLG3 | SYN | discs, large homolog 3 synapse-associated protein 102 | 0.008 | 0.181 | ↑ |
| HOMER1 | SYN | homer homolog 1 | 0.01 | 0.181 | ↑ |
| SNCAIP | SYN | synuclein, alpha interacting protein (synphilin) | 0.01 | 0.181 | ↑ |
| SAP47 | SYN | synapse-associated protein 47kD | 0.02t | 0.181 | ↑ |
| SNCG | SYN | synuclein, gamma | 0.04t | 0.283 | ↑ |
| STX7 | SYN | syntaxin 7 | 0.02t | 0.181 | ↓ |
| ERCC1 | TF | excision repair cross-complementing rodent repair deficiency, complementation group 1 | 0.0003 | 0.052 | ↑ |
| NGFB | NT | nerve growth factor β | 0.03t | 0.233 | ↑ |
| NRP1 | NT | neuropilin 1 | 0.03t | 0.233 | ↑ |
| IGF2R | NT | insulin-like growth factor 2 receptor | 0.003 | 0.122 | ↑ |
t
: trend level change.