Table 1.

Scoring and end point criteria for mice survivability study.

Posture	(Normal = 0; slightly hunched = 1; moderately hunched = 2; severally hunched = 3)
Coat condition	(Normal/groomed = 0; rough = 1; ruffled/unkempt = 2)
Activity/Alertness	(Normal = 0,; reduced exploratory activity = 1; slow moving, dull or depressed = 2; not moving = 3)
Movement/Gait	(Normal = 0; slight incoordination/decreased righting response = 1; tiptoe walking or altered gait involving 1 limb = 2; staggering or paralysis or tremors of 2 or more limbs = 3)

End points.

a) Body weight loss is equal to or greater than 20% of baseline.

b) One limb paralyzed and body weight loss equal to or greater than 15% of baseline.

c) Both limbs paralyzed and body weight loss equal to or greater than 12% of baseline.

d) Assessment score of 3 for any of the following clinical observations: Activity/Alertness or Movement/Gait.

e) A total assessment score of 6 plus 10% body weight loss.

f) Found dead.