Table 3.
Number of mice with seizures and paralysis. During survivability study, the reason for euthanizing the mice was noted. Hind limb paralysis and tremor were also the factors which determine end points. Seizures during opening of the cage in the morning were also noted. *mice with at least one of the Racine stages of seizure and no video recording were done. ** Paralysis of at least one limb.
| Mouse Study | Neuronal Disorder | Treatment groups |
||
|---|---|---|---|---|
| Saline + ZIKV | ZIKV+C100 mg/kg | ZIKV+C200 mg/kg | ||
| Mouse Study II | Seizure* | 4/8 (50%) | 0/8 (0%) | 0/8 (0%) |
| Hind limb paralysis** | 3/8 (37%) | 0/8 (0%) | 0/8 (0%) | |
| Mouse Study III | Seizure* | 3/8 (40%) | – | 0/8 (0%) |
| Hind limb paralysis** | 4/8 (50%) | – | 0/8 (0%) | |