Table 2.

Intention to screen versus usual care primary outcome and post hoc analyses

Analysis	Group	Intention to screen (newly diagnosed atrial fibrillation/all patients (No))	Usual care (newly diagnosed atrial fibrillation/all patients (No))	Odds ratio or hazard ratio (95% CI)	P value
Primary analysis	Intention to screen	144/8874	139/9102	1.06* (0.84 to 1.35)	0.60
Primary analysis	Per protocol	48/4085	139/9102	0.86* (0.61 to 1.20)	0.36
Multiple imputation	Intention to screen	N/A	N/A	1.04* (0.82 to 1.31)	0.75
Multiple imputation	Per protocol	N/A	N/A	0.86* (0.61 to 1.20)	0.37
Cox regression (time to atrial fibrillation)	Intention to screen	144/8874	139/9102	1.06† (0.84 to 1.34)	0.61
Cox regression (time to atrial fibrillation)	Per protocol	48/4085	139/9102	0.86† (0.62 to 1.20)	0.38

N/A=not available.

Intention-to-screen analyses were adjusted for stratification variables (prevalence of atrial fibrillation and region). Per protocol analyses were also adjusted for age (in years), sex (male or female), and history of hypertension, diabetes mellitus, stroke (transient ischaemic attack or stroke), thromboembolism, and heart failure. Although a random intercept was included to adjust for clustering of patients in a care practice, the estimated intraclass correlation was 0. For multiple imputation, we imputed the outcome with group, age, sex, and stratification variables.

^*Odds ratio. †Hazard ratio.