Table 3.

General features and pharmacological interventions targeting TRP channels in neurological diseases.

TRP channels		Ion permeability	General physiological functions	Pharmacological interventions	References
TRPC subfamily	TRPC3	Nonselective cation	Neuronal differentiation, growth cone guidance, vasomotor	Pyr3 for stroke, epilepsy	[77, 100, 101]
	TRPC6	Nonselective cation	Axon guidance, vasomotor, smooth muscle, mechanosensor	Hyperforin for stroke, epilepsy Resveratrol for stroke OAG for AD	[55–58, 89, 101]
TRPV subfamily	TRPV1	Ca2+ permeable	Sensing spicy (hot) peppers, pain sensation, noxious temperature sensing	Dihydrocapsaicin for stroke Capsazepine for epilepsy, AD, PD, stroke Capsaicin for PD, schizophrenia Anandamide for epilepsy AMG9810, oleoylethanolamide for PD	[70, 71, 97–99, 102, 103, 107]
	TRPV2	Weakly Ca2+ selective	Thermal pain sensing, mechanosensor	Cannabidiol for glioblastoma, epilepsy	[87, 105]
	TRPV4	Ca2+ permeable	Osmosensing, warm sensing, nociception, pressure sensing	HC-067047 for stroke, AD, epilepsy GSK1016790A for stroke	[73, 78]
TRPM subfamily	TRPM2	Nonselective cation	Oxidant stress sensing	Tat-M2NX for stroke SB-750139 for AD 2-Aminoethoxydiphenyl borate for AD N-(p-Amylcinnamoyl) anthranilic acid for AD, PD Flufenamic acid for PD	[62, 90, 91, 95]
	TRPM4	Ca2+ impermeable	Mechanosensor	9-Phenanthrol for stroke	[69]
	TRPM7	Mg2+ permeable	Mg2+ homeostasis, entry pathway for trace metals	Carvacrol for stroke	[68]
TRPA subfamily	TRPA1	Nonselective cation	Pungent painful stimuli sensing, noxious cold sensing, mechanosensor	HC-030031 for AD	[93]