Table 2. Unadjusted Outcome Event Rates per 1000 Patient-Days.
| Outcome | No. | |||||
|---|---|---|---|---|---|---|
| Total | With current opioid exposure | Without current opioid exposure | ||||
| Events | Per 1000 patient-days (95% CI) | Events | Per 1000 patient-days (95% CI) | Events | Per 1000 patient-days (95% CI) | |
| Days at risk | 13 666 612 | NA | 373 272 | NA | 13 293 340 | NA |
| Substance misuse–related ADEa | 130 | 0.010 (0.008-0.011) | 45 | 0.121 (0.085-0.156) | 85 | 0.006 (0.005-0.008) |
| Other opioid use–associated ADEb | 3242 | 0.237 (0.229-0.245) | 328 | 0.879 (0.784-0.974) | 2914 | 0.219 (0.211-0.227) |
| GI event | 322 | 0.024 (0.021-0.026) | 31 | 0.083 (0.054-0.112) | 291 | 0.022 (0.019-0.024) |
| Fall or fracture | 1329 | 0.097 (0.092-0.103) | 133 | 0.356 (0.296-0.417) | 1196 | 0.090 (0.085-0.095) |
| Cardiovascular event | 710 | 0.052 (0.048-0.056) | 63 | 0.169 (0.127-0.211) | 647 | 0.049 (0.045-0.052) |
| Serious infection | 927 | 0.068 (0.064-0.072) | 106 | 0.284 (0.230-0.338) | 821 | 0.062 (0.058-0.066) |
| All-cause hospitalization | 9228 | 0.675 (0.662-0.689) | 953 | 2.553 (2.391-2.715) | 8275 | 0.623 (0.609-0.636) |
Abbreviations: ADE, adverse drug event; GI, gastrointestinal; NA, not applicable.
a
Includes diagnosed opioid abuse, dependence, and poisoning.
b
May be smaller than the separate total number of events if an individual is diagnosed with more than 1 adverse drug event during a single health care encounter.