Figure 6.

Bmal1 deficiency in β-cells altered essential proteins related to mitochondrial dynamics. Mitofusin 1, mitofusin 2, and fission 1 protein expressions were analyzed by western blot. Expression levels were normalized to GAPDH protein expression, and each bar represents the mean ± SE of 3 individual experiments. NC: normal control group; siRNA-NC: INS-1 cells treated with negative control siRNA; siRNA-Bmal1: INS-1 cells treated with Bmal1 siRNA. A p value < 0.05 is considered as statistically significant. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001.