Table 1.
Characteristics of neonates included in the analysis
| Algorithm group (n=128) | Non-algorithm group (n=130) | ||
|---|---|---|---|
| Clinical characteristics | |||
| Corrected gestational age, weeks | 40 (39–41) | 40 (39–41) | |
| Birthweight, g | 3465 (3130–3813) | 3350 (2958–3800) | |
| Sex | |||
| Male | 76 (59·4%) | 79 (60·8%) | |
| Female | 52 (40·6%) | 51 (39·2%) | |
| Apgar score at 5 min* | 6 (4–9) | 6 (4–9) | |
| Therapeutic hypothermia | |||
| Cooled | 69 (53·9%) | 59 (45·4%) | |
| Uncooled | 59 (46·1%) | 71 (54·6%) | |
| Final diagnosis | |||
| Mild hypoxic ischaemic encephalopathy | 18 (14·1%) | 14 (10·8%) | |
| Moderate hypoxic ischaemic encephalopathy | 35 (27·3%) | 31 (23·8%) | |
| Severe hypoxic ischaemic encephalopathy | 21 (16·4%) | 11 (8·5%) | |
| Stroke | 15† (11·7%) | 17‡ (13·1%) | |
| Metabolic or genetic disorder | 10§ (7·8%) | 13¶ (10·0%) | |
| Suspected seizures (unconfirmed) | 6 (4·7%) | 14 (10·8%) | |
| Perinatal asphyxia without clinical encephalopathy | 4 (3·1%) | 11 (8·5%) | |
| Sepsis or meningitis | 6‖ (4·7%) | 8 (6·2%) | |
| Intracranial haemorrhage | 3 (2·3%) | 2 (1·5%) | |
| Other | 10** (7·8%) | 9†† (6·9%) | |
| EEG monitoring during study | |||
| Age at start of study‡‡, h | 32·1 (13·6–61·3) | 28·0 (14·0–68·8) | |
| Duration of cEEG monitoring, h | 48·6 (26·1–83·7) | 54·9 (22·3–86·1) | |
| Total duration of cEEG monitoring, h | 6746·7 | 7080·8 | |
Data are median (IQR) or n (%) unless otherwise stated. cEEG=continuous conventional electroencephalography.
119 infants in the algorithm group and 123 infants in the non-algorithm group had data (data were missing in clinical notes for 16 infants).
Three infants also had mild hypoxic ischaemic encephalopathy, two also had moderate hypoxic ischaemic encephalopathy, and one also had severe hypoxic ischaemic encephalopathy.
One infant also had mild hypoxic ischaemic encephalopathy, two also had moderate hypoxic ischaemic encephalopathy, and one also had severe hypoxic ischaemic encephalopathy.
One infant also had severe hypoxic ischaemic encephalopathy.
One infant also had mild hypoxic ischaemic encephalopathy and one also had severe hypoxic ischaemic encephalopathy.
One infant also had mild hypoxic ischaemic encephalopathy.
Six infants had transient metabolic deficit, two had brain malformation, one had multiple congenital abnormalities, and one had persistent pulmonary hypertension of the newborn.
Five infants had seizures of unknown origin, two had congenital cardiac anomaly, one had transient metabolic deficit, and one had brain malformation.
Start of study is defined as time of randomisation or time EEG monitoring commenced (whichever was later).