Table 4.
Secondary outcomes
| Algorithm group | Non-algorithm group | Difference (95% CI*) | ||
|---|---|---|---|---|
| Neonates with seizures | ||||
| Number of neonates with seizures | 32 | 38 | .. | |
| Seizure characteristics | ||||
| Total seizure burden, min | 32·3 (17·0 to 45·1) | 46·8 (20·6 to 63·5) | −14·5 (−37·8 to 15·9) | |
| Maximum seizure burden, min/h | 13·6 (11·0 to 23·5) | 12·9 (9·1 to 20·6) | 0·7 (−7·4 to 9·8) | |
| Median seizure duration, s | 102 (91 to 182) | 108 (77 to 184) | −6 (−84 to 54) | |
| At least one inappropriate antiseizure medication† | 12 | 12 | .. | |
| Percentage (95% CI) | 37·5% (25·0 to 56·3) | 31·6% (21·1 to 47·4) | 5·9% (−14·0 to 26·3) | |
| Neonates without seizures | ||||
| Number of neonates without seizures | 96 | 92 | .. | |
| At least one inappropriate antiseizure medication‡ | 10 | 4 | .. | |
| Percentage (95% CI) | 10·4% (6·3 to 17·7) | 4·3% (2·2 to 9·8) | 6·1% (−0·3 to 13·5) | |
Data are median (bias-corrected 95% CI) unless otherwise stated.
*
Bias-corrected.
†
In the algorithm group, nine infants were given one inappropriate antiseizure medication and three were given two inappropriate antiseizure medications; in the non-algorithm group eight infants were given one inappropriate antiseizure medication, three were given two inappropriate antiseizure medications, one was given three inappropriate antiseizure medications.
‡
In the algorithm group, nine infants were given one inappropriate antiseizure medication and one was given two inappropriate antiseizure medications; in the non-algorithm group, four infants were given one inappropriate antiseizure medication.