Table 5.
Multivariate logistic regression analysis for baseline predictors of non-SVR.
| Variable | Non-SVR12 (No. %) | Univariate analysisOR (95% CI) | P-value | Multivariate analysisOR (95% CI) | P-value |
|---|---|---|---|---|---|
| Age >60 yr. | 37 (49) | 6.68 (4.14–10.79) | <0.001 | 4.46 (2.35–8.46) | <0.001 |
| Male gender | 30 (40) | 0.71 (0.44–1.14) | 0.16 | 0.94 (0.52–1.70) | 0.84 |
| Treatment experienced | 46 (61) | 4.40 (2.73–7.08) | <0.001 | 1.26 (0.65–2.43) | 0.47 |
| HCV PCR >800,000 | 32 (42) | 3.07 (1.91–4.94) | <0.001 | 0.90 (0.44–1.83) | 0.78 |
| ALT >ULN | 59 (78) | 1.56 (0.89–2.71) | 0.11 | 1.38 (0.70–2.73) | 0.34 |
| AST >ULN | 53 (70) | 0.82 (0.49–1.36) | 0.44 | ||
| Albumin <3.5 g/L | 4 (5.3) | 1.08 (0.38–3.05) | 0.88 | ||
| Total bilirubin >ULN | 3 (4) | 1.41 (0.42–4.70) | 0.57 | ||
| WBC <4×109/L | 2 (3) | 1.83 (0.42–8.04) | 0.41 | ||
| Hemoglobin <10 g/dl | 2 (2.6) | 0.38 (0.09–1.57) | 0.18 | 0.74 (0.15–3.53) | 0.70 |
| Platelets <150 (×109/L) | 15 (20) | 0.96 (0.53–1.7) | 0.89 | ||
| Creatinine >ULN | 4 (5) | 1.40 (0.49–3.99) | 0.52 | ||
| Compensated cirrhosis | 44 (58) | 68.0 (37.3–123.7) | <0.001 | 53.91(26.49–109.6) | <0.001 |
Bold values represent statistical significance. P-value < 0.25 in the univariate analysis were included in the multivariate analysis.