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. 2020 Sep 2;11:559627. doi: 10.3389/fphar.2020.559627

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Copyright © 2020 Johnston, Thacker, Desjardins, Kulyk, Romay-Tallon, Kalynchuk and Caruncho

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of corticosterone (CORT) and ketamine on reelin-IR cells in the gyrus subgranular zone (SGZ). (A) Representative photomicrographs of reelin-ir cells in the dorsal SGZ. Stereological analyses were undertaken at 40× magnification. (B) Effects of treatment on reelin-ir cells in the dorsal SGZ. CORT significantly decreased the number of positive cells, which was rescued by acute ketamine administration. There were no effects of CORT or reelin in the ventral hippocampus. All data are expressed as mean±SD. Veh/Veh, vehicle/vehicle; Veh/Ket, vehicle/ketamine; CORT/Veh, CORT/vehicle; CORT/Ket, CORT/ketamine. *p < 0.05 vs. Veh/Veh, ^#p < 0.05, **p < 0.01 vs. CORT/Veh.