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. 2020 Sep 2;11:559627. doi: 10.3389/fphar.2020.559627

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Copyright © 2020 Johnston, Thacker, Desjardins, Kulyk, Romay-Tallon, Kalynchuk and Caruncho

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of corticosterone (CORT) and ketamine on doublecortin (DCX)-IR cells in the gyrus subgranular zone (SGZ). (A) Representative photomicrographs of DCX-ir cells in the SGZ. (B) Effects of treatment on DCX-ir cells. CORT significantly decreased the number of positive cells, which was not rescued with acute ketamine administration. All data are expressed as mean±SD. Veh/Veh, vehicle/vehicle; Veh/Ket, vehicle/ketamine; CORT/Veh, CORT/vehicle; CORT/Ket, CORT/ketamine. **p < 0.01 vs. Veh/Veh, ^##p < 0.01 vs. CORT/Veh.