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. 2020 Sep 2;11:559627. doi: 10.3389/fphar.2020.559627

Figure 6.

Figure 6

The effect of reelin on synaptic-level proteins in cerebellar synaptosomes. (A) Representative Western Blot images of synaptic-level protein expression in the cerebellum after reelin incubations on synaptosomes from corticosterone (CORT)-treated animals. Ladder presented is Spectra Multicolor High Range Protein Ladder (Thermofisher, #26625). (B) Effects of reelin incubations on levels of postsynaptic density-95 (PSD-95). All levels stayed the same. (C) Effects of reelin incubations on levels of mammalian target of rapamycin (mTOR). Lower concentrations increased the levels above vehicle and CORT, but higher concentrations decreased mTOR levels. (D) Effects of reelin on levels of p-mTOR. All concentrations were significantly different from both vehicle and CORT, paralleling the findings with mTOR. (E) Effects of ketamine and reelin on the active ratio of mTOR. All data are expressed as mean±SD. R5, 5nм reelin; R10, 10nм reelin; R50, 50nм reelin. ##p < 0.01, ###p < 0.001, ####p < 0.0001 vs. vehicle, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. CORT.