Table 2.

Bioactions of SPMs on ion transport and mucus secretion, demonstrated in non-CF models.

Ion transport and hydration
Conditions	SPMs	Models	Bioactions	References
In vitro studies
Other	LXA4	Human bronchial epithelial cells (primary and 16HBE14o-)	Stimulates Ca2+ -dependent Cl- secretion	Bonnans et al., 2003
Acute lung injury	LXA4	Rat primary alveolar type II cells	Stimulates expression of CFTR	Yang et al., 2013
	Mar1		Stimulates expression of ENaC α, β and Na-K-ATPase α1, β1	Zhang et al., 2017
In vivo studies
Acute lung injury	LXA4	Sprague-Dawley rat	Stimulate airway fluid clearance	Yang et al., 2013
	RvD1			Wang Q. et al., 2014
	Mar1			Zhang et al., 2017
Mucus secretion
Conditions	SPMs	Models	Bioactions	References
In vitro studies
Other	LXA4	Sprague-Dawley Rat primary conjunctival goblet cells	Increases glycoconjugate secretion	Hodges et al., 2017
	RvD1			Lippestad et al., 2017
	RvD2			Botten et al., 2019
	RvE1			Lippestad et al., 2017
	Mar1		Increases glycoconjugate secretion Counter-regulates histamine-induced secretion	Olsen et al., 2020
	RvD1 & RvE1	Sprague-Dawley Rat and Human primary conjunctival goblet cells	Inhibits leukotriene-induced glycoconjugate secretion	Dartt et al., 2011
	RvD1 & AT-RvD1		Counter-regulates histamine-induced secretion	Li et al., 2013
In vivo studies
Asthma	RvE1	BALB/c mice	Lowers mucus score	Aoki et al., 2008