Table 5.

Bioactions of SPMs on micro-RNA regulation, demonstrated in non-CF models.

micro-RNA
Conditions	SPMs	Models	Bioactions	References
In vitro studies
TNF-α treatment	LXA4	Human umbilical vein endothelial cells	Up-regulates miR-126-5p (related to endothelial repair and VCAM-1 expression)	Codagnone et al., 2017
TGF-β-induced fibrosis	LXA4	Human renal epithelial HK-2 cells Human mesangial cells Rat renal NRK49F fibroblasts	Up-regulates miR let-7c and reduces human renal fibrosis Decreases miR let-7c level in rat fibroblasts	Brennan et al., 2013
Other	RvD1 RvE1 RVD2 & PD1	Human peripheral blood mononuclear cells	Regulates miR-146b, miR-21, miR-208 and miR-219-5p Regulates miR-219-5p and miR-21 but not miR146b Regulate miR-146b and miR-21 but not miR-219-5p	Fredman et al., 2012
In vivo studies
Chronic renal fibrosis	LXA4	Male wistar rats	Up-regulates miR let-7c and reduces renal fibrosis	Brennan et al., 2013
Acute peritonitis	RvD1 analog	Male FVB mice	Temporally controls miRNAs, increases miR21 and miR146b, decreases miR208a (NF-kB signaling) and miR219 (LTB4 production)	Recchiuti et al., 2011