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. 2020 Sep 3;13:8783–8794. doi: 10.2147/OTT.S258450

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© 2020 Zhou et al.

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Overexpression of RIG-I in mouse and human macrophages promoted cell apoptosis of the corresponding liver cancer cells. (A) Hepa1-6 cells were cultured with conditioned medium from peritoneal macrophages infected with RIG-I lentivirus or negative control lentivirus. After 48 hours, FACS assay was performed to test the cell apoptosis of Hepa1-6 cells with Annexin V-FITC/PI staining method. (B) The apoptosis rate of Hepa1-6 cells cultured with conditioned medium was shown in histogram. **p<0.01, between the groups with conditioned medium from peritoneal macrophages infected with RIG-I lentivirus or negative control lentivirus. (C) The apoptosis rate of H22 cells was shown in histogram. **p<0.01, between the groups with conditioned medium from peritoneal macrophages infected with RIG-I lentivirus or negative control lentivirus. (D) The apoptosis rate of SMMC7721 cells cultured with conditioned medium was shown in histogram. **p<0.01, between the groups with conditioned medium from THP-1 derived macrophages infected with RIG-I lentivirus or negative control lentivirus. (E) The apoptosis rate of HepG2 cells was shown in histogram. **p<0.01, between the groups with conditioned medium from THP-1 derived macrophages infected with RIG-I lentivirus or negative control lentivirus.