Table 1.
Baseline Clinical Characteristics.
| Variable | HFrEF n=171 |
HFpEF n=374 |
No Prior CV Disease n=70 |
P value for HFrEF vs HFpEF |
|---|---|---|---|---|
| Age (yrs.) | 60 (50 – 69) | 64 (53 – 74) | 33 (26 – 41) | 0.002 |
| Female | 30.4% | 56.4% | 68.6% | <0.001 |
| Race | 0.026 | |||
| White or Caucasian | 59.1% | 62.8% | 60.0% | |
| Black or African American | 35.7% | 35.0% | 28.6% | |
| Biplane EF | 30 (25 – 35) | 54 (48 – 58) | 57 (53 – 62) | NA |
| Clinical Characteristics | ||||
| Atrial fibrillation | 25.7% | 32.9% | 0.0% | 0.093 |
| COPD | 7.0% | 11.5% | 0.0% | 0.107 |
| Hypertension | 81.3% | 80.7% | 0.0% | 0.882 |
| Type II Diabetes | 38.0% | 38.2% | 2.8% | 0.960 |
| Prior PCI/CABG | 53.8% | 48.4% | 0.0% | 0.242 |
| Prior CVA/TIA | 16.4% | 18.7% | 0.0% | 0.509 |
| ACE-I/ARB use | 65.5% | 61.8% | 0.0% | 0.403 |
| Beta Blocker use | 67.3% | 58.8% | 0.0% | 0.061 |
| BUN (mg/dL) | 17.0 (13.0 – 24.0) | 16.0 (12.0 – 23.0) | 10.0 (8.00 – 12.0) | 0.552 |
| Sodium (mmol/L) | 139 (137 – 141) | 139 (137 – 140) | 139 (137 – 140) | 0.655 |
| Creatinine (mg/dL) | 1.10 (0.90 – 1.40) | 1.00 (0.80 – 1.40) | 0.80 (0.70 – 0.90) | 0.093 |
| eGFR (mL/min/1.73m2) | 72.0 (56.6 – 91.9) | 69.6 (51.2 – 89.6) | 99 (83.3 – 111) | 0.426 |
| NT-proBNP (pg/mL) | 1073 (425 – 3117) | 428 (170 – 1296) | 21.0 (20.0 – 49.0) | <0.001 |
| MAP (mmHg) | 88 (80 – 100) | 90 (82 – 101) | 86 (79 – 92) | 0.187 |
| SBP (mmHg) | 120 (105 – 136) | 128 (116 – 142) | 116 (106 – 122) | <0.001 |
| DBP (mmHg) | 73 (67 – 81) | 71 (64 – 80) | 72 (65 – 80) | |
| Heart rate (beats/min) | 72 (63 – 84) | 66 (59 – 76) | 71 (62 – 78) | <0.001 |
NT-proBNP = n-terminal pro-brain natriuretic peptide, COPD=chronic obstructive pulmonary disease, PCI = percutaneous coronary intervention, CABG=coronary artery bypass surgery, CVA=cerebrovascular accident, TIA=transient ischemic attack, ACE-I=angiotensin converting enzyme inhibitor, ARB=angiotensin receptor blocker, BUN=blood urea nitrogen, eGFR=estimated glomerular filtration rate, MAP=mean arterial pressure, SBP=systolic blood pressure. No p-value is reported for EF comparison because the groups are expected to be different.