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. 2020 Sep 2;11:556845. doi: 10.3389/fphar.2020.556845

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Copyright © 2020 Zhao, Tao, Shang, Zhang, Ruan, Zhang, Zhou, Aiello, Lai and Qu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baicalin treatment increased proliferation and survival of newborn granule cells in the dentate gyrus of chronic corticosterone (CORT)-induced depression model mice. (A) Images of Ki-67 immunohistochemistry in DG granular neurons; (B) Images of BrdU immunohistochemistry in DG granular neurons; (C) Enlarged image of the Ki-67 cells; (D) The total number changes of Ki-67 cells; (E) Enlarged image of the BrdU cells; (F) The total number changes of BrdU cells. The results are mean ± SEM (n=3 mice/group), scale bar=50 μm. ^#P < 0 .05 and ^##P < 0.01 versus Control, ^*P < 0.05 and ^**P < 0.01 versus CORT.