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. 2020 Sep 2;11:556845. doi: 10.3389/fphar.2020.556845

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Copyright © 2020 Zhao, Tao, Shang, Zhang, Ruan, Zhang, Zhou, Aiello, Lai and Qu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baicalin promotes maturation of newborn granule cells in the dentate gyrus of chronic corticosterone (CORT)-induced depression model mice. (A) Hippocampal dentate gyrus (DG) images of the adult newborn neurons (red: DCX; green: BrdU; Blue: NeuN), scale bar=50 μm; (B) Enlarged images of the newborn immature neurons (morphology of DCX+/NeuN+/BrdU+ cells, yellow arrows) and the mature neurons (morphology of DCX-/NeuN+/BrdU+ cells, white arrows), scale bar=20 μm; (C) The number of the newborn immature neurons; (D) The number of adult born mature neurons; (E) The proportion of DCX-/NeuN+/BrdU+ cells (percentage of BrdU cells). The results are mean ± SEM (n=3 mice/group). ^#P < 0 .05 and ^##P < 0.01 versus Control, ^*P<0.05 and ^**P<0.01 versus CORT.