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. 2020 Sep 2;11:556845. doi: 10.3389/fphar.2020.556845

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Copyright © 2020 Zhao, Tao, Shang, Zhang, Ruan, Zhang, Zhou, Aiello, Lai and Qu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baicalin enhances dendritic complexity without affecting spine density of granule cells in the dentate gyrus of chronic corticosterone (CORT)-induced depression model mice. (A) Dendritic arbors measured by Golgi staining and reconstruction of the dendritic arbors in DG granular neurons, scale bar=50 μm; (B) Sholl analyses of total dendritic length in DG granule neurons; (C) Sholl analyses of the numbers of dendritic points in DG granule neurons; (D) Representative graphs of dendritic spines in hippocampal DG granule neurons, scale bar =10 μm; (E) The density of the total spines; (F) The density of the mushroom-shaped spines. Data is represented as means ± SEM (n=3 mice/group, (B, C) 3 neurons were analyzed for each animal; (E, F) 10 neurons were analyzed for each animal). ^##P < 0.01 versus Control, ^*P < 0.05 and ^**P < 0.01 versus CORT.