Fig. 1.

RTX adhesin domain architecture. (A) The domain architectures for three exemplar RTX adhesins are shown, with their N termini on the left. Beta sandwiches and RTX repeats – domains that appear in all known RTX adhesins – are coloured blue and red, respectively. Two known domains used for bacterial adhesion are PA14 and vWFA, coloured yellow and purple, respectively. The repeats used for the tetra-tandemer constructs in this study are underlined in orange. (B) Weblogos for all the beta-sandwich repeats present in MhLap or AhLap. The residues are colour-coded red for negatively charged, blue for positively charged, black for hydrophobic, and green for polar uncharged/small aliphatic. Asterisks are above calcium-binding residues.