Table 5.
Effect of sub-chronic administration of ethyl acetate extract of the leaf of Diospyros mespiliformis on some biochemical parameters of rats.
| Dose (mg/kg) |
||||
|---|---|---|---|---|
| Parameters | 250 | 500 | 750 | DW |
| AST (U/L) | 0.02 ± 0.0 | 0.05 ± 0.0 | 0.06 ± 0.0 | 0.06 ± 0.0 |
| ALT (U/L) | 0.05 ± 0.0 | 0.04 ± 0.0 | 0.04 ± 0.0 | 0.05 ± 0.0 |
| ALP (U/L) | 62.07 ± 8.14 a | 71.38 ± 9.70 a | 76.21 ± 10.1 b | 72.83 ± 14.4 a |
| Total bilirubin | 0.73 ± 0.11 | 0.63 ± 0.10 | 0.54 ± 0.14 | 1.17 ± 0.55 |
| Total cholesterol (mg/dl) | 0.37 ± 0.10 | 0.20 ± 0.04 | 0.29 ± 0.08 | 0.40 ± 0.12 |
| Total protein (g/dl) | 6.94 ± 0.16 | 7.45 ± 0.32 | 7.20 ± 0.44 | 6.87 ± 0.25 |
| Albumin (g/dl) | 3.64 ± 0.08 | 3.57 ± 0.08 | 3.59 ± 0.10 | 3.67 ± 0.07 |
| Sodium | 13328.0 ± 92.87 a | 13384.0 ± 84.00 a | 13776.0 ± 94.95 a | 14084.0 ± 56.00 a |
| Potassium | 3.88 ± 0.10 | 4.14 ± 0.10 | 4.20 ± 0.18 | 4.20 ± 0.06 |
| Urea (mg/dl) | 44.61 ± 0.97a | 54.30 ± 2.50 b | 39.27 ± 2.35 a | 48.00 ± 2.35 b |
| Creatinine (mg/dl) | 0.67 ± 0.0 a | 0.67 ± 0.0 a | 0.67 ± 0.0 a | 0.67 ± 0.0 a |
Values are presented as mean ± standard error of mean. DW = Distilled water (5 mL/kg).
AST, aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase.
Means in the same row compared to control with different superscript letters are significantly different (P<0.05).