Table 2.
The role of some lncRNAs in osteoporosis and their mechanisms through osteoblasts and osteoclasts and targets
| LncRNA ID | Target molecule and pathway | Effects on osteoblasts differentiation |
|---|---|---|
| lncRNA HIF1A-AS1 [46] | SIRT1 | Promote osteoblast differentiation |
| LncRNA HoxA-AS3 [47] | EZH2, H3K27me3, Runx2 | Promote osteoblast differentiation |
| lncRNA MALAT1 [102] | miR-143, miR-204 | Promote osteoblast differentiation |
| lncRNA MODR [103] | miR-454 | Promote osteoblast differentiation |
| LncRNA KCNQ1OT1 [104] | miR-214 | Promote osteoblast differentiation |
| LncRNA NTF3-5 [105] | miR-93-3p | Promote osteoblast differentiation |
| LncRNA POIR [106] | miR-182 | Promote osteoblast differentiation |
| LncRNA Linc-ROR [107] | miR-145 | Promote osteoblast differentiation |
| LncRNA H19 [100, 101] | miR-675, miR-141, miR-22 | Promote osteoblast differentiation |
| LncRNA H19 [53] | Wnt/β-catenin pathway, | Inhibit osteoblast differentiation |
| LncRNA-DANCR [48, 49] | EZH2, H3K27me3, Runx2, p38 MAPK | Inhibit osteoblast differentiation |
| LncRNA ANCR [50] | Wnt/β-catenin pathway | Inhibit osteoblast differentiation |
| LncRNA HOTAIR [51] | Wnt/β-catenin pathway | Inhibit osteoblast differentiation |
| lncRNA p21 [52] | E2, Wnt/β-catenin pathway | Inhibit osteoblast differentiation |
| Lnc-AK045490 [54] | β-catenin, TCF1, LEF1 and Runx2 | Inhibit osteoblast differentiation |
| Lnc-AK016739 [55] | osteoblastic TF | Inhibit osteoblast differentiation |
| lncRNA UCA1 [56] | BMP-2/(Smad1//5/8) | Inhibit osteoblast differentiation |
| LncRNA MEG3 [57, 58] | Wnt/β-catenin signaling pathway | Promote osteoblast differentiation |
| IGF1 | Inhibit osteoblast differentiation | |
| LncRNA HOTAIR [108] | miR-17-5p, SMAD7 | Inhibit osteoblast differentiation |
| LncRNA MIAT [109] | miR-150-5p | Inhibit osteoblast differentiation |
| lncRNA-ORLNC1 [111] | miR-296 | Inhibit osteoblast differentiation |
| LncRNA MEG3 [112] | miR-133a-3p | Inhibit osteoblast differentiation |
| LncRNA TSIX [52] | miR-30a-5p, and Runx2 | Promote osteoblast apoptosis |
| lncRNA TUG1 [86] | PTEN | Promote osteoclast differentiation |
| lncRNA AK077216 [87] | NIP45, NFATc1 | Promote osteoclast differentiation |
| lncRNA SNHG15 [88] | RANK/RANKL pathyway | Promote osteoclast differentiation |
| LncRNA-Jak3 [89] | Nfatc1, Ctsk | Promote osteoclast differentiation |
| LncRNA LINC00311 [90] | DDL3 | Promote osteoclast differentiation |
| LncRNA RP11-498C9.17 [91] | HDAC4 | Inhibit osteoclast differentiation |
| LncRNA Bmncr [92] | RANK | Inhibit osteoclast differentiation |
| LncRNA NONMMUT037835.2 [93] | RANK, NF-κB/MAPK signaling pathway | Inhibit osteoclast differentiation |
| LncRNA-NEF [94] | IL-6 | Inhibit osteoclast differentiation |