Table 3.
The role of some circRNAs in osteoporosis and their mechanisms through osteoblasts and osteoclasts and targets
| circRNA ID | Target molecule and pathway | Mechanisms that affect osteoporosis through osteoblasts and osteoclasts |
|---|---|---|
| circRNA_0016624 [59] | miR-98, BMP2 | Promote osteoblast differentiation |
| circRNA AFF4 [60] | miR-7223-5p | Promote osteoblast differentiation |
| CircRNA CDR1as [61] | miR-7, GDF5, Smad1/5/8 and p38 MAPK | Promote osteoblast differentiation |
| circHIPK3 [62, 63] | miR-124 | Promote osteoblast differentiation |
| circRNA436 [111] | miR-108, miR-335 | Promote osteoblast differentiation |
| CircRNA BANP [112] | miRNA-146a, PDGFRA | Promote osteoblast proliferation |
| circRNA ITCH [112] | miR-34a, DUSP1 | Promote osteoblast proliferation |
| circIGSF11 [64] | miR-199b-5p | Inhibit osteoblast differentiation |
| hsa_circ_0127781 [111] | miR-210, miR-335 | Inhibit osteoblast differentiation |
| CircRNA_28313 [95] | miR-195a, CSF1 | Promote osteoclast differentiation |
| CircRNA_007438 [96] | miRNA-6338, miRNA-7028-3p | Promote osteoclast differentiation |
| circRNA_005108 [96] | miRNA-6975-3p,miRNA-6516-5p, miRNA-486b-5p, miRNA-31-3p | Inhibit osteoclast differentiation |