Table 2.

Composite TD-1473 and tofacitinib plasma and colonic tissue pharmacokinetic parameters [n = 4 per time point] following oral administration of TD-1473 [10 mg/kg] or tofacitinib [10 mg/kg] in male Balb/c mice.

Analyte	TD-1473		Tofacitinib
Dose	10 mg/kg		10 mg/kg
Matrix	Plasma	Colon	Plasma	Colon
C max [µM]	0.003 ± 0.002	9.168 ± 10.293	0.62 ± 0.075	8.252 ± 2.740
AUC [µM·h]	0.006 ± 0.002	22.186 ± 21.888	0.720 ± 0.117	29.385 ± 14.597
Tissue/plasma ratio [Cmax]	2636		13
Tissue/plasma ratio [AUC]	3883		41

C_max and AUC values are expressed as the mean ± SD.

AUC, area under the concentration–time curve; C_max, maximal plasma concentration; SD, standard deviation.