Table 3.

Percentage of Patients With Grade ≥3 Toxicity as a Function of Their Plasma U Level. Median, 25th et 75th Percentile (Pctl).

	Number of patients (of 472)	Patients with toxicity grade 3 number (%)	Patients with toxicity grade 4 number (%)	Patients with toxicity grade 5 number (%)
U < 16ng/mL	280	47 (16.8%)	53 (18.9%)	8 (2.9%)
Median [U] ng/mL	-	9.97	8.90	12.48
25th Pctl_75th Pctl	-	6.55_13.96	6.3_12.7	11.1_14.8
16ng/ml ≤ U < 150ng/mL	178	50 (28.1%)	73 (41.0%)	21 (11.8%)
Median [U] ng/mL	-	23.60	25.28	33.51
25th Pctl_75th Pctl	-	19.63_31.81	21.0_31.8	25.0_58.8
U ≥ 150 ng/mL	14	0	2 (14.3%)	12 (85.7%)
Median [U] ng/mL	-	-	-	2083
25th Pctl_75th Pctl	-	-	-	417.5_3263.2

“-” = not applicable