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. Author manuscript; available in PMC: 2021 Aug 28.
Published in final edited form as: J Nat Prod. 2020 Aug 10;83(8):2490–2500. doi: 10.1021/acs.jnatprod.0c00492

Table 3.

EC50 Values of Compounds 1, 3, and 5–8Against SK-MEL-28 Cancer Cells

compound Dark (μM) Visa (nM) PIvisb Redc (nM) PIredd
1 130.0 ± 12.0 53.5 ± 1.0 2430 59.2 ± 6.0 2196
3 43.7 ± 5.9 14.7 ± 8.0 2973 15.7 ± 6.0 2783
5 39.3 ± 6.2 10.3 ± 1.0 3816 15.3 ± 3.0 2569
6 132.0 ± 13.0 172.0 ± 43.0 767 603.0 ± 41.0 219
7 > 300 135.0 ± 56.0 > 2222 1280 ± 20.0 > 234
8 98.7 ± 1.7 176.0 ± 23.0 561 2550 ± 60.0 39
a

Vis: 16 hours drug-to-light interval followed by 100 J/cm2 broadband visible-light irradiation

b

PIvis = phototherapeutic index (ratio of dark EC50 to visible-light EC50)

c

Red: 16 hours drug-to-light interval followed by 100 J/cm2 light irradiation with 625 nm LEDs

d

PIred = phototherapeutic index (ratio of dark EC50 to red-light EC50).