Table 2.

Ongoing ClinicalTrial.gov registered trials regarding OLV during thoracic surgery

Title of trial	Location of trial	Interventions and outcome measures	ClinicalTrial.gov registration #
Effect of Lung Protective One-lung Ventilation with Fix and Variable PEEP on Oxygenation and Outcome	Hungary, single center	Interventions Under tidal volume 6 mL/kg/PBW, compare fix 5 cmH2O PEEP and variable PEEP with recruitment maneuvers. Outcome Measures Primary: intraoperative oxygenation Secondary: postoperative complications and survival	NCT03968120
Optimal Level of PEEP in Protective One-lung Ventilation	Korea, single center	Interventions Under tidal volume 5 mL/kg/PBW, compare 3, 6, and 9 cmH2O PEEP and variable PEEP. Outcome Measures Primary: modified lung ultrasound score Secondary: intraoperative desaturation, PaO2/FiO2, plasma inflammatory cytokines, postoperative desaturation and pulmonary complication	NCT03856918
Electrical Impedance Tomography in One-Lung Ventilation	Chile, single center	Interventions Compare three tidal volumes (4, 6 and 8 mL/kg/PBW) and two PEEP’s (6 cmH20 and best PEEP obtained after a recruitment maneuver and decremental titration). Outcome Measures Ventilation/perfusion ratio, pulmonary mechanics, arterial gas measurement	NCT03728010
Individualized vs Low PEEP in One Lung Ventilation	US, single center	Interventions Compare individualized PEEP (max lung compliance) and low PEEP (5 cmH2O). Outcome Measures Primary: cerebral oximetry Secondary: arterial and venous blood oxygen tension, venous blood oxygen saturation, cardiac output, phenylephrine dose	NCT03569774
Individualized Perioperative Open-Lung Ventilatory Strategy During One-Lung Ventilation (iPROVE-OLV)	International, multicenter	Interventions Under tidal volume 5–6 mL/kg/PBW, compare alveolar recruitment maneuver plus PEEP titration trial and lung protective ventilation (PEEP 5 cmH2O). Outcome Measures Primary: postoperative pulmonary complications Secondary: postoperative complications, length of hospital stay	NCT03182062
Protective Ventilation with High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery (PROTHOR)	International, multicenter	Interventions Under tidal volume 5 mL/kg/PBW, compare higher PEEP (PEEP 10 cmH2O + lung recruitment) and lower PEEP (PEEP 5 cmH2O only). Outcome Measures Primary: postoperative pulmonary complications	NCT02963025

PaO₂/FiO₂ Partial pressure of arterial oxygen/fraction of inspired oxygen ratio, PBW Predicted body weight, PEEP Positive end-expiratory pressure, OLV One-lung ventilation