Table 3. Product Purities, PurR and PurS, and Masses, mR and mS (Dry Product), as Well as Process Times, tproc, and Productivities, PrR and PrS, of All CPCD Experiments Performeda.
Exp. | mseed [g] | msol.feed [g] | mR [g] | PurR [%] | mS [g] | PurS [%] | tproc [h] | PrR [g/(kg h)] | PrS [g/(kg h)] |
---|---|---|---|---|---|---|---|---|---|
1 | 0.1 | (37) | 0.8 | 99 | 4.3 | 0.36 | |||
2 | 0.1 | 20 | 1.4 | 98 | 6.3 | 0.45 | |||
3 | 0.1 | 4 | 2.4 | 97 | 0.6 | 91 | 7.2 | 0.68 | 0.17 |
4 | 0.1 | 3.5 | 1.8 | 98 | 1.2 | 95 | 6.7 | 0.55 | 0.37 |
5 | 0.3 | 10 | 4.3 | 98 | 3.5 | 97 | 5.8 | 1.49 | 1.26 |
6 | 1.1 | 20 | 19.6 | 80 | 11.2 | 98 | 3.5 | 9.31 | 6.63 |
7 | 1.1 | 30 | 13.8 | 97 | 8.8 | 98 | 1.9 | 14.27 | 9.39 |
8 | 1.1 | 30 | 31.6 | 69 | 8.9 | 98 | 3.3 | 14.03 | 5.47 |
9 | 1.1 | 30 | 11.3 | 98 | 14.5 | 98 | 2.7 | 9.05 | 10.89 |
10 | 1.1 | 30 | 16.1 | 93 | 14.9 | 98 | 4.0 | 7.67 | 7.55 |
11 | 1.1 | 40 | 32.7 | 97 | 16.9 | 98 | 4.0 | 16.86 | 9.13 |
Seeding was always done with (R)-guaifenesin except for Exp. 9, where the (S)-enantiomer was used.