Fig. 5.

KLF4 expression sensitizes PDX ALL cells to chemotherapy. a Experiments were set up as shown in Fig. 3, except that transgene expression was initiated when a high tumor burden was achieved (day 30) and maintained during low-dose combination chemotherapy (0.2 mg/kg vincristine + 35 mg/kg cyclophosphamide; days 31–65). Dox was added to the drinking water starting on day 30 when starting the low dose combination chemotherapy to initiate transgene expression (light red- and light green-striped background). b Tumor growth was monitored and analyzed as shown in Fig. 3