Figure 1.

Ternary phase diagrams of conglomerates illustrating calculations of driving forces used in the SCM demonstrated (a) at starting point O (lines Ow_sat,1⁰ and Ow_sat,2) and (b) for solvated systems, at any process point O′ (lines O′w_sat,1 and O′w_sat,2). Points 1′ and 2′ are the respective solvated compounds of preferred and counter enantiomers. The driving force correspondent to each enantiomer at each time t is calculated from the intersection between the line connecting pure phase corner (1, 2, 1′, or 2′) and current state O′ (dash-dotted lines) and the metastable solubility (dotted lines).^13,35,36