Table 3.
Summary of Changes in Gene Expression Following Exposure to AgNPs.
| Liver | Spleen | Kidney | Heart | Lung | Brain | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Healthy | MetS | Healthy | MetS | Healthy | MetS | Healthy | MetS | Healthy | MetS | Healthy | MetS | |
| Chemokine (C-C motif) ligand 2 (CCL2) | ↑ | ↑ | - | - | - | ↓ | - | ↑ | ↓ | ↓ | ↑ | - |
| Chemokine (C-X-C motif) ligand 1 (CXCL1) | - | ↑ | ↑ | - | ↑ | ↓ | - | ↑ | ↓ | ↓ | ↓ | ↓ |
| Chemokine (C-X-C motif) ligand 2 (CXCL2) | ↑ | ↑ | - | - | ↑ | - | - | ↑ | - | ↓ | - | - |
| Tumor necrosis factor α (TNF-α) | ↑ | ↑ | ↑ | - | ↓ | - | - | ↑ | ↓ | - | ↓ | - |
| Transforming growth factor β (TGF-β) | ↑ | ↑ | ↑ | - | ↓ | ↑ | - | - | ↓ | ↓ | ↓ | - |
| Heme oxygenase 1 (HO-1) | ↑ | ↑ | ↑ | - | - | ↑ | - | - | ↓ | - | ↓ | ↓ |
| Interleukin 4 (IL-4) | - | - | ↑ | ↓ | ||||||||
| Interleukin 13 (IL-13) | - | - | - | ↓ | ||||||||
Statistically significant increases and decreases in expression as compared to unexposed groups are denoted by “up” and “down” arrows, respectively. Lack of any statistically significant change is indicated by a dash.