TABLE 3.

Baseline and 48 hour SOFA score components by organ failure

Variable	Overall (n = 428)	Worsening organ failure (n = 152)	No worsening organ failure (n = 276)	P‐value*
Baseline
Neurologic	1 (0;3)	1 (0;3)	1 (0;3)	0.7150
Cardiovascular	3 (3;4)	3 (3;4)	3 (3;4)	0.8414
Coagulation	0 (0;1)	0 (0;1)	0 (0;0)	<0.0001
Liver	0 (0;0)	0 (0;0)	0 (0;0)	0.0437
Renal	1 (0;3)	1.5 (0.5;3)	1 (0;3)	0.9513
Respiration	2 (0;3)	2 (0;3)	2 (0;3)	0.1916
48 ha	n = 351a	n = 75a	n = 276
Neurologic	2 (1;3)	3 (2;3)	2 (0;3)	<0.0001
Cardiovascular	1 (1;4)	4 (4;4)	1 (1;4)	<0.0001
Coagulation	1 (0;2)	1 (0;3)	0 (0;1)	0.0001
Liver	0 (0;0)	0 (0;0)	0 (0;0)	0.0003
Renal	1 (0;2)	2 (0;2)	0 (0;2)	<0.0001
Respiration	0 (0;2)	2 (1;3)	0 (0;1)	<0.0001

Data are median (IQR). *Wilcoxon rank‐sum for all tests of significance.

^a = 77 patients who died early no longer included.