Table 1.
Effects of SGF on body weight, kidney/body ratio, lead concentration in blood, urine and kidney of rats with lead-induced nephrotoxicity.
| Group | Body weight increase (g) | Kidney/body ratio (mg/g) | Blood lead(μg/100 mL) | Urine lead(μg/100 mL) | Kidney lead(μg/100 g) |
|---|---|---|---|---|---|
| Control | 201 ± 18.2a | 7.1 ± 0.82c | 0.18 ± 0.07e | 7.97 ± 0. 81d | 0.41 ± 0.01e |
| Pb exposed | 176 ± 16.9b | 11.3 ± 1.03a | 10.21 ± 0.93a | 250.47 ± 19.48a | 32.09 ± 0.31a |
| Pb + DMSA | 202 ± 19.7a | 8.6 ± 0.91c | 0.83 ± 0.14d | 129.36 ± 22.10b | 4.2 ± 0.07d |
| Pb + SGF-50 | 194 ± 18.8a | 10.0 ± 0.98b | 5.45 ± 0.40b | 83.86 ± 9.07c | 18.5 ± 0.15b |
| Pb + SGF-100 | 198 ± 20.1a | 9.4 ± 0.74b | 4.95 ± 0.34b | 97.20 ± 7.29c | 16.2 ± 0.06b |
| Pb + SGF-200 | 200 ± 19.4a | 8.9 ± 0.85c | 3.83 ± 0.23c | 107.64 ± 10.55b | 13.6 ± 0.05c |
The results are expressed as the mean ± SD, n = 8; Different letters in the same column indicate significant differences (P < 0.05). Pb exposed, 0.5% lead acetate in drinking water; DMSA, meso-2,3-dimercaptosuccinic acid, 70 mg/kg; SGF-50, SGF-100, SGF-200, Smilax glabra flavonoids extract, 50 mg/kg, 100 mg/kg, and 200 mg/kg.