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. 2020 Sep 2;8:627. doi: 10.3389/fcell.2020.00627

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Copyright © 2020 Gong, Xiao, Li, Li, Gao and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteins differentially expressed between de novo hair follicle areas and no hair follicle areas within the scar region with upregulation of IL-36α in the inner area of the wound. (A) Heat map representing 129 differentially expressed proteins between de novo hair follicle areas (inner) and no hair follicle areas (outer) within the scar region. (B) Principal Component Analysis (PCA) reveals distinct separation between tissue types (inner and outer scar areas). Real-time quantitative PCR (qPCR) (C) and western blot (D) analyzed the difference of IL-36α expression between inner (H = de novo hair follicle area) and outer (NH = no hair follicle area) scar areas at post-wound day (PWD) 15 (n = 3; *p < 0.05).