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. 2020 Sep 2;8:627. doi: 10.3389/fcell.2020.00627

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Copyright © 2020 Gong, Xiao, Li, Li, Gao and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-36α causes an increase in the expression of hair follicle stem/progenitor cell markers in mice skin. A total of 50 μL of 1 ng/μL mrIL-36α dissolved in PBS or PBS only was injected intradermally into two separate dorsal regions of skin of 7-week-old mice for 3 days. (A) The relative mRNA expression levels of hair follicle stem/progenitor cell markers (Lgr5, Lgr6, Lrig1, K15, and CD34) in mrIL-36α-injected region and control region were evaluated using real time quantitative PCR (n = 4). Total epithelial cells were subjected to flow cytometry analysis after staining for CD34, CD49f and Pcad. Flow cytometry analysis of hair follicle stem/progenitor cells marked by CD34⁺CD49f⁺ (B,C) and CD34^– CD49f⁺Pcad^hi (D,E) (*p < 0.05, **p < 0.005, n = 4).