Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 2;8:627. doi: 10.3389/fcell.2020.00627

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Gong, Xiao, Li, Li, Gao and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

mrIL-36α causes increased expression level of β-catenin and IL-6 and activates STAT3. A total of 50 μL of 1 ng/μL mrIL-36α dissolved in PBS or PBS only was injected intradermally into two separate dorsal regions of skin of 7-week-old mice for 3 days. (A,B) Total mRNA was isolated from mrIL-36α-injected region and control region, and mRNA levels of LEF1, Wnt5a, DKK1, LRP5, β-catenin (key genes in Wnt/β-catenin pathway) and IL-6 were analyzed by qPCR (n = 4). (C) The phosphorylation level of STAT3 in the IL-36α-treated region and the control region analyzed by western blot (*p < 0.05, n = 3).