TABLE 4.

Univariate and multivariate Cox regression analysis of the 6-marker-based classifier with OS in the training set and validating set.

Features	Univariate COX		Multivariate COX
	HR (95% CI)	P	HR (95% CI)	P
Training set
Age (>70 vs. ≤70)	1.519 (1.049, 2.200)	0.027
Gender (Male vs. Female)	0.831 (0.562, 1.231)	0.356
Pathological stage (III + IV vs. I + II)	2.210 (1.387, 3.521)	0.001	1.826 (1.135, 2.937)	0.013
Histologic grade (High vs. Low)	1.942 (0.477, 7.899)	0.354
Diagnosis subtype (Papillary vs. Non-papillary)	0.674 (0.441, 1.028)	0.067
6-marker-based classifier (High risk vs. Low risk)	1.738 (1.435, 2.103)	<0.001	1.636 (1.342, 1.995)	<0.001
Validating set
Age (>70 vs. ≤70)	1.853 (1.106, 3.105)	0.019	1.861 (1.084, 3.195)	0.024
Gender (Male vs. Female)	0.916 (0.508, 1.649)	0.769
Pathological stage (III + IV vs. I + II)	2.573 (1.301, 5.089)	0.007	2.497 (1.234, 5.052)	0.011
Histologic grade (High vs. Low)	1.278 (0.019, 8.561)	0.394
Diagnosis subtype (Papillary vs. Non-papillary)	0.571 (0.280, 1.163)	0.123
6-marker-based classifier (High risk vs. Low risk)	3.781 (2.117, 6.754)	<0.001	3.166 (1.751, 5.727)	<0.001

OS, Overall survival; HR, Hazard ratio; 95% CI, 95% Confidence interval. Bold values are significant to p < 0.05.