TABLE 5.

Univariate and multivariate Cox regression analysis of the 6-marker-based classifier with RFS in TCGA database.

Features	Univariate COX		Multivariate COX
	HR (95% CI)	P	HR (95% CI)	P
Age (>70 vs. ≤70)	1.117 (0.802, 1.557)	0.513
Gender (Male vs. Female)	0.857 (0.596, 1.232)	0.404
Pathological stage (III + IV vs. I + II)	2.879 (1.810, 4.578)	<0.001	2.623 (1.643, 4.187)	<0.001
Histologic grade (High vs. Low)	3.345 (0.826, 13.544)	0.091
Diagnosis subtype (Papillary vs. Non-papillary)	0.642 (0.431, 0.956)	0.029
6-marker-based classifier (high risk vs. low risk)	1.911 (1.365, 2.677)	<0.001	1.696 (1.207, 2.382)	0.002

RFS, Recurrence-free survival; TCGA, The Cancer Genome Atlas; HR, Hazard ratio; 95% CI, 95% Confidence interval. Bold values are significant to p < 0.05.