TABLE 4.
Comparison of pedigree between the LS group and the FCCTX group.
| Variable | LS group (N = 47) | FCCTX group (N = 46) | t/χ2 value | p-Value |
| Patients with cancer (cases)a | 4.02 ± 2.48 | 4.46 ± 1.79 | −0.969 | 0.335 |
| Male patients(cases)a | 2.28 ± 1.72 | 2.72 ± 1.38 | −1.365 | 0.176 |
| Female patients (cases)a | 1.74 ± 1.42 | 1.74 ± 1.18 | 0.020 | 0.984 |
| First degree relatives (cases)a | 1.98 ± 1.69 | 2.04 ± 1.10 | −0.219 | 0.827 |
| Second degree relatives (cases)a | 1.04 ± 1.55 | 1.41 ± 1.72 | −1.092 | 0.278 |
| Cases of cancera | 5.13 ± 3.10 | 5.07 ± 1.83 | 0.118 | 0.906 |
| Patients with CRC (cases)a | 3.26 ± 2.08 | 3.26 ± 1.67 | −0.014 | 0.989 |
| Cases of CRCa | 3.91 ± 2.54 | 3.54 ± 1.68 | 0.829 | 0.410 |
| Patients with right colon cancer (cases)a | 1.45 ± 1.02 | 1.13 ± 1.05 | 1.479 | 0.143 |
| Cases of right colon cancera | 1.49 ± 1.06 | 1.13 ± 1.05 | 1.643 | 0.104 |
| Right colon cancer | 2.200 | 0.138 | ||
| Occurrence | 38 (80.9%) | 31 (67.4%) | ||
| Absence | 9 (19.1%) | 15 (32.6%) | ||
| Patients with left colon cancer (cases)a | 1.72 ± 1.19 | 1.13 ± 0.86 | 2.746 | 0.007 |
| Cases of left colon cancera | 1.94 ± 1.54 | 1.15 ± 0.92 | 2.977 | 0.004 |
| Left colon cancer | 3.181 | 0.074 | ||
| Occurrence | 43 (91.5%) | 36 (78.3%) | ||
| Absence | 4 (8.5%) | 10 (21.7%) | ||
| Patients with rectal cancer (cases)a | 0.49 ± 0.69 | 1.26 ± 0.98 | −4.415 | <0.001 |
| Cases of rectal cancera | 0.49 ± 0.69 | 1.26 ± 0.98 | −4.415 | <0.001 |
| Rectal cancer | 11.962 | 0.001 | ||
| Occurrence | 18 (38.3%) | 34 (73.9%) | ||
| Absence | 29 (61.7%) | 12 (26.1%) | ||
| Patients with extra-colorectal cancer (cases)a | 1.09 ± 1.37 | 1.46 ± 1.47 | −1.263 | 0.210 |
| Cases of extra-colorectal cancersa | 1.21 ± 1.49 | 1.52 ± 1.55 | −0.982 | 0.329 |
| Extra-colorectal cancer | 0.666 | 0.415 | ||
| Occurrence | 30 (63.8%) | 33 (71.7%) | ||
| Absence | 17 (36.2%) | 13 (28.3%) | ||
| Patients with synchronous or metachronous CRCa | 0.53 ± 0.75 | 0.28 ± 0.46 | 2.137 | 0.046 |
| Synchronous or metachronous CRC | 5.506 | 0.019 | ||
| Occurrence | 21 (44.7%) | 10 (21.7%) | ||
| Absence | 26 (55.3%) | 36 (78.3%) | ||
| Patients with synchronous or metachronous extra-colorectal cancera | 0.40 ± 0.68 | 0.30 ± 0.59 | 0.755 | 0.452 |
| Synchronous or metachronous extra-colorectal cancer | 0.739 | 0.390 | ||
| Occurrence | 15 (31.9%) | 11 (23.9%) | ||
| Absence | 32 (68.1%) | 35 (76.1%) | ||
| Earliest onset age of cancer (years)a | 36.66 ± 8.75 | 40.11 ± 9.26 | −2.147 | 0.036 |
| Earliest onset age of CRC (years)a | 37.53 ± 8.63 | 41.93 ± 7.77 | −2.584 | 0.011 |
| Earliest onset age of extra-colorectal cancer (years)* | 45.00 ± 10.27 | 45.48 ± 19.96 | −0.119 | 0.905 |
aThese data are presented as mean ± standard deviation; other values are presented as number of patients followed by percentage in parentheses. * These data are limited to families that developed extra-colorectal cancer. LS, Lynch syndrome; CRC, colorectal cancer; FCCTX, familial colorectal cancer type X.