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. 2020 Aug 28;14:153. doi: 10.3389/fnbeh.2020.00153

FIGURE 1.

FIGURE 1

Experiment 1: BNST CRFR1 antagonist effect on incubation of fentanyl craving. (A) Experimental timeline: we trained rats to self-administer fentanyl for 3 h/day for 10 days. On forced abstinence Day 1 and Day 30, we measured lever responding under extinction conditions. (B) Fentanyl infusions + cues earned across the 10 daily self-administration sessions. (C) Rats discriminated Active from Inactive Lever during self-administration training. (D,E) Incubation test data showing cues earned on FR1, 20 s TO schedule (D) and Active/Inactive Lever pressing (E) on Day 1 and Day 30 of forced abstinence for vehicle (open bars) treated and R121919 treated (filled bars) conditions. (F) Time course of Active and Inactive Lever presses on Day 30 test for both treatment groups. *p < 0.05, **p < 0.01, different from Session 1 in (B), Lever main effect in (C), different from Day 1 in (D), and Treatment main effect in (F). R12 = R121919. n = 13 Veh, n = 15 R12. Data are mean ± SEM.