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. 2020 Aug 28;8:814. doi: 10.3389/fcell.2020.00814

FIGURE 1.

FIGURE 1

The cognitive dysfunction in aging mice. n = 8 for 2- or 12-month mice, n = 6 for 24-month mice. Data were shown as mean ± SEM. (A) The recognition indexes were significantly reduced in 12- and 24-month old mice as compared to 2-month old mice at 3 and 24 h after the training session in the novel object recognition test. ∗∗P < 0.01 versus the corresponding 2-month old mice by two-way ANOVA with repeated measures followed by post hoc Tukey test. (B) The percentages of spontaneous alterations were significantly reduced in 12- and 24-month old mice as compared to 2-month old mice in the Y maze test. ∗∗P < 0.01 versus the corresponding 2-month old mice by one-way ANOVA with repeated measures followed by post hoc Tukey test. (C) The number of arm entries was significantly reduced in 24-month old mice, but not in 12-month old mice in the Y maze test. ∗∗P < 0.01 versus the corresponding 2-month old mice by one-way ANOVA with repeated measures followed by post hoc Tukey test. (D) The learning curve was examined for 5 days in the Morris water maze test. ∗P < 0.05 versus 2-month old mice at the corresponding time point by two-way ANOVA with repeated measures followed by post hoc Tukey test. (E,F) Platform crossing times in the probe trial of the MWM test at 1 (E) and 24 h (F) after the training session. ∗P < 0.01 versus 2-month old mice by two-tailed unpaired Student’s t-test. (G,H) The average escape latency to reach the previous platform location was examined at 1 (G) and 24 h (H) after the training session. ∗∗P < 0.01 versus 2-month old mice by two-tailed unpaired Student’s t-test. (I,J) Total distance of movement was examined at 1 (I) and 24 h (J) after the training session. Two-tailed unpaired Student’s t-test.