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. 2020 Aug 28;8:814. doi: 10.3389/fcell.2020.00814

FIGURE 2.

FIGURE 2

Depression- and anxiety-like behavior in aging mice. n = 8 for 2- or 12-month mice, n = 6 for 24-month mice. Data were shown as mean ± SEM. (A,B) The immobility time was significantly increased in 12- and 24-month old mice in the forced swimming test (FST) (A) and tail suspension test (TST) (B) as compared to 2-month old mice. ∗∗P < 0.01 versus 2-month old mice by one-way ANOVA with repeated measures followed by post hoc Tukey test. (C) The total distance of 24-month-old mice in the open field test was less than that of 2-month-old mice. ∗∗P < 0.01 versus 2-month old mice by one-way ANOVA with repeated measures followed by post hoc Tukey test. (D–F) The percentage of distance in the central area (D), the time spent in the central area (E), and the entries in the central area (F) were significantly reduced in 12- and 24-month old mice in the open field test as compared to 2-month-old mice. ∗∗P < 0.01 versus 2-month old mice by one-way ANOVA with repeated measures followed by post hoc Tukey test. (G,H) The percentages of the time spent in open arms (G) and open arms entries (H) were both significantly reduced in 12- and 24-month old mice as compared to 2-month old mice in the elevated plus maze test. ∗∗P < 0.01 versus 2-month old mice by one-way ANOVA with repeated measures followed by post hoc Tukey test. (I) The total arm entries of 24-month old mice were less than those of 2-month old mice. ∗∗P < 0.01 versus 2-month old mice by one-way ANOVA with repeated measures followed by post hoc Tukey test.