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Nociceptive response in different ages of mice. Paw withdrawal frequencies (PWF) in response to 0.07 g (A,B) and 0.4 g (C,D) von Frey filaments and paw withdrawal latency (PWL) on response to heat stimulation (E,F) on the left (A,C,E) and right (B,D,F) sides. n = 8 for 2- or 12-month mice, n = 6 for 24-month mice. Data were shown as mean ± SEM. One-way ANOVA with repeated measures followed by post hoc Tukey test.
