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. 2020 Aug 28;8:814. doi: 10.3389/fcell.2020.00814

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Copyright © 2020 Li, Su, Cai, Cao, Miao, Zang, Gao, Xu, Yang, Tao and Ai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of a PPI network to analyze protein-protein interactions. Top 50 differentially expressed genes (DEGs) were selected according to the connection degree of genes in the ACC (A,B), amygdala (C,D), and hippocampus (E,F) of 12- (A,C,E) and 24- (B,D,F) month old mice. The size of the node is determined by the connection degree. The connection degree reflects the importance of the gene in the network as it represents the number of nodes connected. The red, blue, and purple circles represent the genes related to inflammation, apoptosis and both inflammation and apoptosis, respectively.