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. 2020 Aug 27;11:929. doi: 10.3389/fneur.2020.00929

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Copyright © 2020 Shang, Hong, Xie, Tu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H₂O₂ treatment induced senescent phenotypes and upregulation of total and phosphorylated tau protein in rat astrocytes. (A–C) Statistical analysis of SAHF- (A), SA-β-gal- (B), and 53BP1-foci- (C) positive cells in rat astrocytes treated with different concentrations of H₂O₂ for 2 days. (D) Protein levels of 53BP1 and p53 (a), p21 and p16 (b), p-tau and tau (c) in rat astrocytes after treated with different concentrations of H₂O₂. (E–G) quantification of (D). Data indicate the mean values calculated from three independent experiments (±SD).