Table 3.
SNPs and overall survival
| N | Median, m (95% CI) | HR (95% CI)a | P-valuea | HR (95% CI)b | P-valueb | |
|---|---|---|---|---|---|---|
| MMP9 rs17577 | 0.044 | 0.20 (0.40) | ||||
| G/G | 54 | 7.4 (4.8–13.2) | 1 (reference) | 1 (reference) | ||
| G/A | 14 | 5.1 (1.9–11.0) | 1.83 (0.95–3.53) | 1.59 (0.79–3.22) | ||
| MMP9 rs17576 | 0.32 | 0.21 (0.40) | ||||
| A/A | 32 | 7.4 (4.6–15.5) | 1 (reference) | 1 (reference) | ||
| A/G | 25 | 5.1 (4.3–10.1) | 1.51 (0.85–2.68) | 1.45 (0.81–2.62) | ||
| G/G | 12 | 7.0 (0.8–11.0) | 1.25 (0.60–2.62) | 2.06 (0.84–5.06) | ||
| ST6GALNAC5 rs1146671 | 0.68 | 0.52 (0.80) | ||||
| G/G | 27 | 5.8 (3.0–13.2) | 1 (reference) | 1 (reference) | ||
| G/A | 24 | 7.1 (4.3–16.1) | 0.90 (0.50–1.63) | 0.91 (0.48–1.73) | ||
| A/A | 18 | 7.2 (2.8–14.7) | 1.21 (0.62–2.37) | 1.38 (0.68–2.78) | ||
| ST6GALNAC5 rs1883778 | 0.14 | 0.028 (0.12) | ||||
| G/G | 27 | 4.6 (3.0–9.3) | 1 (reference) | 1 (reference) | ||
| G/A | 22 | |||||
| A/A | 21 | |||||
| G/A or A/A | 43 | 9.4 (5.0–13.4) | 0.68 (0.40–1.16) | 0.53 (0.30–0.93) | ||
| ST6GALNAC5 rs17368584 | 0.97 | 0.28 (0.48) | ||||
| T/T | 26 | 7.4 (3.8–14.7) | 1 (reference) | 1 (reference) | ||
| T/C | 23 | 5.0 (4.3–13.1) | 1.03 (0.56–1.92) | 0.69 (0.36–1.33) | ||
| C/C | 16 | 6.1 (2.0–13.4) | 0.96 (0.49–1.88) | 0.56 (0.27–1.18) | ||
| ITGAV rs1839123 | 0.90 | 0.73 (0.83) | ||||
| G/G | 38 | 7.1 (4.6–11.0) | 1 (reference) | 1 (reference) | ||
| G/A | 21 | 6.9 (3.0–16.2) | 0.89 (0.50–1.60) | 1.02 (0.54–1.92) | ||
| A/A | 9 | 14.7 (0.5–17.3) | 0.89 (0.41–1.95) | 0.73 (0.31–1.71) | ||
| ITGAV rs1448424 | 0.98 | 0.95 (0.95) | ||||
| A/A | 39 | 7.1 (4.8–11.0) | 1 (reference) | 1 (reference) | ||
| A/G | 22 | 6.9 (3.0–15.3) | 0.96 (0.54–1.71) | 0.90 (0.47–1.71) | ||
| G/G | 8 | 9.8 (0.5–17.3) | 1.04 (0.47–2.27) | 0.97 (0.42–2.27) | ||
| ITGAV rs10171481 | 0.10 | 0.018 (0.12) | ||||
| A/A, A/G | 58 | 5.3 (4.3–10.1) | 1 (reference) | 1 (reference) | ||
| A/A | 41 | |||||
| A/G | 17 | |||||
| G/G | 11 | 15.5 (2.8–22.7) | 0.58 (0.29–1.15) | 0.39 (0.18–0.85) | ||
| ITGAV rs11902171 | 0.12 | 0.65 (0.83) | ||||
| G/G | 40 | 5.8 (3.8–9.3) | 1 (reference) | 1 (reference) | ||
| G/C | 20 | 15.3 (4.8–16.3) | 0.60 (0.32–1.11) | 0.73 (0.36–1.49) | ||
| C/C | 10 | 5.9 (1.1–13.1) | 1.14 (0.53–2.44) | 1.07 (0.49–2.33) | ||
| ITGB1 rs2298141 | 0.49 | 0.62 (0.83) | ||||
| G/G | 44 | 7.1 (4.3–14.7) | 1 (reference) | 1 (reference) | ||
| G/A | 21 | |||||
| A/A | 4 | |||||
| G/A or A/A | 25 | 6.9 (4.8–11.3) | 1.20 (0.71–2.02) | 1.16 (0.65–2.06) | ||
| ITGB1 rs1187071 | 0.57 | 0.21 (0.40) | ||||
| T/T | 55 | 7.4 (4.6–11.3) | 1 (reference) | 1 (reference) | ||
| T/C | 15 | 5.3 (3.8–14.7) | 1.20 (0.63–2.28) | 1.56 (0.78–3.15) | ||
| ITGB1 rs11009151 | 0.65 | 0.88 (0.93) | ||||
| T/T | 45 | 5.8 (4.3–14.7) | 1 (reference) | 1 (reference) | ||
| T/A | 22 | |||||
| A/A | 2 | |||||
| T/A or A/A | 24 | 8.1 (4.8–13.1) | 1.12 (0.66–1.91) | 1.05 (0.59–1.86) | ||
| ITGB3 rs5918 | 0.010 | 0.024 (0.12) | ||||
| T/T or T/C | 61 | 8.0 (4.9–13.1) | 1 (reference) | 1 (reference) | ||
| T/T | 47 | |||||
| T/C | 14 | |||||
| C/C | 8 | 4.0 (1.1–6.9) | 2.66 (1.13–6.25) | 2.72 (1.14–6.48) | ||
| ITGB3 rs4642 | 0.014 | 0.16 (0.40) | ||||
| A/A or A/G | 59 | 8.0 (4.9–13.1) | 1 (reference) | 1 (reference) | ||
| A/A | 40 | |||||
| A/G | 19 | |||||
| G/G | 11 | 4.3 (1.1–6.9) | 2.31 (1.08–4.93) | 1.80 (0.79–4.08) | ||
| ITGB3 rs3809865 | 0.82 | 0.72 (0.83) | ||||
| A/A | 40 | 7.4 (4.3–11.3) | 1 (reference) | 1 (reference) | ||
| A/T | 16 | 6.4 (2.0–16.1) | 1.16 (0.61–2.23) | 1.16 (0.58–2.32) | ||
| T/T | 13 | 6.9 (3.8–15.5) | 0.92 (0.48–1.76) | 1.34 (0.64–2.82) | ||
| KLF4 rs2236599 | 0.16 | 0.048 (0.16) | ||||
| G/G | 45 | 7.4 (4.8–13.2) | 1 (reference) | 1 (reference) | ||
| G/A | 16 | |||||
| A/A | 9 | |||||
| G/A or A/A | 25 | 4.8 (3.8–10.1) | 1.44 (0.83–2.49) | 2.12 (1.01–4.45) | ||
| CXCR4 rs2680880 | 0.76 | 0.013 (0.12) | ||||
| A/A or A/T | 55 | 7.1 (4.8–13.1) | 1 (reference) | 1 (reference) | ||
| A/A | 25 | |||||
| A/T | 30 | |||||
| T/T | 15 | 4.6 (2.8–11.0) | 1.09 (0.60–2.00) | 2.30 (1.19–4.44) |
Abbreviations: A, adenine; C, cytosine; CI, confidence interval; G, guanine; HR, hazard ratio; m, months; rs, reference SNP number; T, thymine.
a
Based on the log-rank test in the univariable analysis.
b
Based on Wald test in the multivariable analysis within Cox regression model adjusted for age at diagnosis of CRC (< 57 vs 57+ years), primary tumor site (colon vs rectal), BM location (supratentoriell vs infratentoriell or both) and Karnosky performance status (< 90, 90–100). FDR-adjusted P-values are shown in parentheses.